Related conditions

Some people with APS will also have other autoimmune conditions, as may other members of their family. APS has been linked with many other autoimmune conditions including rheumatoid arthritis and celiac disease, but the main autoimmune ‘cousins’ of APS are:

Lupus

Lupus is often the autoimmune condition most closely associated with APS; the first ever group of patients found to have antiphospholipid antibodies (aPL) were lupus patients.

Approximately 30%-40% of lupus patients have aPL, and around 15% of these people develop antiphospholipid syndrome which increases their risk of clotting.

With lupus, the autoimmune system attacks its own organs such as the kidneys, and produces common symptoms such as fatigue, joint pain and skin rashes.

For an overview, please visit the NHS Choices website and for more in-depth information, please visit the Lupus UK website.

Raynaud's phenomenon

Raynaud’s phenomenon (usually just called Raynaud’s) is a common condition that affects the blood supply to certain parts of the body, usually the fingers and toes. During a Raynaud’s attack, the blood vessels go into a temporary spasm which blocks the flow of blood. This causes the affected area to change colour to white, then blue and then finally red as the blood flow returns.

You may also experience pain, numbness and pins and needles in the affected body parts. Symptoms can last from a few minutes to several hours. Raynaud’s is usually triggered by cold temperatures or by anxiety or stress.

For an overview, please visit the NHS Choices website and for more in-depth information please visit the Scleroderma and Raynaud’s UK website.

Sjögren's syndrome

A significant number of APS patients will also have Sjögren’s syndrome (pronounced show-grens) – another autoimmune disease in which white blood cells attack the body’s tear and saliva glands, reducing the amount of saliva and tears produced.

This can cause dry eyes, dry mouth, digestive problems, fatigue, aches and joint pains along with other symptoms.

For an overview, please visit the NHS Choices website and for more in-depth information please go to the British Sjögrens Association website.

Thyroid disease

Many patients with APS have relatives with a history of thyroid disease, particularly Graves’ disease.

Graves’ disease is the most common cause of overactive thyroid and is another autoimmune disease. It can run in families and can occur at any age, although it is most common in women aged 20-40 years old. You are more likely to develop Graves’ disease if you smoke.

If you have Graves’ disease, your eyes may also be affected, causing discomfort and double vision. This is known as Graves’ ophthalmopathy. You may find that your eyes bulge out, or appear more prominent.

For an overview, please visit the NHS Choices website and for more in-depth information please go to the British Thyroid Foundation’s website.

Diagnosis and treatment

APS is usually diagnosed from a combination of a positive blood test and symptoms. If you are under 50 and have suffered a thrombosis, or have had more than one pregnancy loss, you should discuss with your doctor whether you need blood tests.

Living with APS

Living with a long-term condition means that you may have to make some adjustments to your life, and APS is no exception. By making certain adjustments you should be able to help stabilise your condition, reduce symptoms and increase your overall well-being.

Newly diagnosed

Receiving a new diagnosis of APS can be frightening, and no doubt you will want to know exactly what APS is. Following this, you will likely have a great many more questions to ask about the condition and how it can affect you. We are here to help!

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